Manuscript on simulating interacting active droplets

We uploaded a preprint on the main results from Ajinkya’s PhD thesis on arxiv. In this slightly technical work, we propose a new numerical algorithm to simulate interacting active droplets.

The main idea of the algorithm is to only simulate the relevant degrees of freedom, which in our case are droplet radii & positions as well as large-scale information about the background field. This reduced set of variables can be evolved in time much faster than the usual fine-grained fields necessary for a full description of the phase separation process, e.g., using a Cahn-Hilliard equation. We are now in a position to simulate systems of much larger size for longer evolution times, optionally also with (active) chemical turnover and imposed chemical gradients; see the inset. To develop the algorithm, and in particular couple the dynamics of the droplets to the background field, we leveraged analytical results to bridge length scales. In the future, this approach will allow us to explorer dynamics that are relevant to the behavior of droplets in biological cells and other challenging situations that were previously not numerically accessible.

Ajinkya defended his Ph.D.

Ajinkya defended his Ph.D. today and thus became the second student to graduate in our group! He gave an extremely clear talk and answered all questions by the committee. His work on “Effective simulations of interacting droplets” describes a novel method to simulate active droplets that interact with each other. His work will form the basis of future extensions that we will work on in the group. In the long term, his work will thus contribute to effective simulations of biomolecular condensates in complex situations, like those in cells. Congratulations, Ajinkya!

Jan defended his Ph.D.

Jan defended his Ph.D. this week with flying colors! He gave a brilliant talk and mastered the following discussion to earn his doctorate. His work on “Chemical Reactions as Control Mechanisms for Biomolecular Condensates” will form the basis for multiple follow-up projects in our group and hopefully also helps biologists to interpret their data on condensate regulation. Stay tuned for his thesis, which will soon be published officially and on our website.

Seeking Ph.D. student

Seeking Ph.D. student

We seek a Ph.D. student to strengthen our team. We offer a collaborative, international, and fun environment to conduct a thesis in Theoretical Biological Physics, which likely will involve inter-disciplinary work with biologists, chemists, and other physicists around the world. We offer multiple projects in the broader field of theoretical descriptions of phase separation in biological cells, but are also interested in other topics.

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Postdoc opening

Postdoc opening

We are looking to expand our team and offer a postdoc position. We’re looking for fun people, who are interested in working collaboratively in a team of physics and collaborate with biologists, chemists, and other physicists around the world. We offer multiple projects in the broader field of theoretical descriptions of phase separation in biological cells, but are also interested in other topics of Theoretical Biological Physics.

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New paper on droplet growth in elastic matrices

New paper on droplet growth in elastic matrices

We assessed the formation of droplets in elastic gels using a new model in a recent publication in PNAS. In our study, we simulated how environmental factors such as temperature influence the size of oil droplets in elastic matrices. Our study will also help understanding droplet formation in biological cells, where biological molecules self-organize in condensates.

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